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We are developing novel machine learning algorithms and incorporating them into closed-loop autonomous systems to accelerate knowledge capture in the lab and in
Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The
Balancing the growth of the bioeconomy with the inherent risks associated with the potential misuse of artificial intelligence (AI) related to nucleic acid
NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species to identify advantageous biological
Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that
The Cellular Engineering Group is working to engineer components of living cells to sense environmental fluctuations induced by contaminants within their
We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune
Consortium hosted by NIST dedicated to authoritative characterization of benchmark human genomes. Sign up for General GIAB and Analysis Team email lists
This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
Diverse biological sciences, from engineering to epidemiology, benefit from an increased understanding of how genetic code (genotype) determines downstream
Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such
Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a
Measurements of the performance of engineered organisms are typically not reproducible or comparable across different laboratories. So, to enable meaningful
Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require
The Cellular Engineering Group works to provide metrology for rapid, successful translation of safe, effective bioproducts based on cell-free expression systems
Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups
The National Institute of Standards and Technology Genome Editing Consortium addresses the measurements and standards needed to increase confidence and lower
Genome Editing technologies have transformed the potential of biosciences and biotechnology, by providing precision engineering tools that enable modifications
NOW AVAILABLE The NIST monoclonal antibody (NISTmAb) reference material, RM 8671, is intended for use in evaluating the performance of methods for determining